HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Dimethylamino-3'-trifluoromethylacrylophenone → 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| Reactant | HCID 178418806 | HCID 178418806 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine | HCID 19756203 | — |
Reaction Steps
A mixture of 8.31 g. of 3-aminopyrazole, 24.32 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone and 100 ml. of glacial acetic acid is refluxed for 8 hours and evaporated in vacuo to an oil. This oil is treated as described in Example 1, giving the desired product, m.p. 103°-104.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04236005 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-b7406f825afd4748944c91433263895e |
| Source note | uspto-grants-1980_11 |