HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 3-Bromo-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine | HCID 19756203 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3-Bromo-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine | HCID 11473317 | — |
Reaction Steps
A 3.75 g. portion of N-bromosuccinimide is added to a solution of 5.26 g. of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine in 50 ml. of chloroform producing an exothermic reaction. The mixture is refluxed on a steam bath for 15 minutes and then treated as described in Example 14, giving the desired product, m.p. 138°-140° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04236005 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-21519e58cdea481bab73317e92e49b91 |
| Source note | uspto-grants-1980_11 |