HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 22598929, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 10649815 | HCID 10649815 | — |
| Reactant | HCID 21881488 | HCID 21881488 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22598929 | HCID 22598929 | — |
Reaction Steps
A solution of 1-(3-((1-(triphenylmethyl)imidazol-2-yl)amino)propyl)-1H-indazole-5-carboxylic acid, methyl 3-amino-2-(((2,6-dimethyl-4-(3-(N-(3-(2-(2-(3-((phenylmethoxy)carbonylamino)propoxy)ethoxy)ethoxy)propyl)carbamoyl)propoxy)phenyl)sulfonyl)amino)propanoate, DIEA, and HBTU in anhydrous DMF are stirred at ambient temperatures under nitrogen for 4 h. The DMF is removed under vacuum and the resulting residue is dissolved in EtOAc and washed with water, saturated NaHCO3, and saturated NaCl. The EtOAc layer is dried (MgSO4) and concentrated to dryness. The crude product is purified by flash chromatography on silica gel using EtOAc/MeOH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07321045B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-56677de53dcb4dd2892f4ec6774d83ae |
| Source note | uspto-grants-2008_01 |