HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → HCID 23520121, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 22598957 | HCID 22598957 | — |
| Reactant | HCID 23520133 | HCID 23520133 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 23520121 | HCID 23520121 | — |
Reaction Steps
A solution of 7-(3-[(tert-butoxy)carbonylamino]-propoxy}-1-(3-([1-(triphenylmethyl)imidazol-2-yl]amino)propyl)-1H-indazole-5-carboxylic acid is treated with Hunig's base and HBTU, then is stirred for about 10 min. The reaction mixture is treated with methyl 3-amino-2(S)-(2,4,6-trimethyl-benzenesulfonyl)aminopropionate. The product is then isolated via chromatography. The methyl ester is saponified using LiOH in THF, and the trityl and boc protecting groups are removed by treatment with trifluoroacetic acid to give the title compound. It is purified by reversed phase preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07321045B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-4eb2a20281634cbb80ddb7e08bbe4a1e |
| Source note | uspto-grants-2008_01 |