HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide dimethyl acetal → 3-Dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | Propiophenone, 3'-(trifluoromethyl) | HCID 137064 | — |
| Product | 3-Dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone | HCID 54529942 | — |
Reaction Steps
A mixture of 25 g. of m-trifluoromethylpropiophenone and 25 ml. of dimethylformamide dimethylacetal is refluxed overnight and then evaporated to an oil. The oil is dissolved in hexane and the solution is refrigerated giving crystals of the desired product, m.p. 53°-55° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04236005 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-5fff47f6d35c4586a4b592f9e37d7b09 |
| Source note | uspto-grants-1980_11 |