1-(2-Amino-5-bromophenyl)ethan-1-one → HCID 68865368, compound

HRID 2252542Notes

Reaction equation

HRID 2252542 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].[S:12]1[CH:16]=[CH:15][N:14]=[C:13]1[Li]>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([C:13]1[S:12][CH:16]=[CH:15][N:14]=1)([OH:11])[CH3:10]

Participants

3

Reactant 2

HCID 110747461-(2-Amino-5-bromophenyl)ethan-1-oneHCID 178506781HCID 178506781, compound

Product 1

HCID 68865368HCID 68865368, compound

Procedure

Prepared from 1-(2-amino-5-bromo-phenyl)-ethanone and 2-thiazolyl lithium generally according to the procedure described in example 1. 1H-NMR (DMSO-d6) δ 7.70 (d, J=3.3 Hz, 1H), 7.64 (d, J=3.2 Hz, 1H), 7.28 (d, J=2.4 Hz, 1H), 7.10 (dd, J=8.5, 2.4 Hz, 1H), 6.92 (s, 1H), 6.55 (d, J=8.5 Hz, 1H), 5.50 (s, 2H), 1.90 (s, 3H).

Sources & evidence

ORD record
ord-0c92698f56fa4d62bb2f8c42a6b5a1f0
Source dataset
uspto-grants-2008_01
Patent number
US07323455B2

Reaction notes

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