HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromofuran-2-carbonitrile → 4-(5,5-Dimethyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-7-yl)-2-furonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromofuran-2-carbonitrile | HCID 21986220 | — |
| Reactant | HCID 68865814 | HCID 68865814 | — |
| Product | 4-(5,5-Dimethyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-7-yl)-2-furonitrile | HCID 24956372 | — |
Reaction Steps
Prepared from 7-bromo-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one and 4-bromofuran-2-carbonitrile generally according to the coupling procedure described in examples 82 and 1. 1H-NMR (DMSO-d6) δ 9.96 (s, 1H), 8.61 (s, 1H), 8.19 (s, 1H), 7.56 (d, J=1.9 Hz, 1H), 7.50 (dd, J=8.3, 2.0 Hz, 1H), 7.14 (d, J=8.4 Hz, 1H), 4.24 (s, 2H), 1.59 (s, 6H); MS (ES) m/z 283 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07323455B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-75e0d2ce43034139b47b22b9f0beb0d7 |
| Source note | uspto-grants-2008_01 |