2-Fluorophenylboronic acid → HCID 24956012, compound

HRID 2252600Notes

Reaction equation

HRID 2252600 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][O:8][C:7]([CH3:14])([CH3:13])[C:6]=2[CH:15]=1.[F:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1B(O)O>>[CH3:13][C:7]1([CH3:14])[O:8][CH2:9][C:10](=[O:12])[NH:11][C:5]2[CH:4]=[CH:3][C:2]([C:18]3[C:17]([F:16])=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:15][C:6]1=2

Participants

3

Reactant 2

HCID 27343542-Fluorophenylboronic acidHCID 688658147-bromo-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one

Product 1

HCID 24956012HCID 24956012, compound

Procedure

Prepared from 7-bromo-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one and 2-fluoro benzeneboronic acid generally according to the coupling procedure described in example 1. 1H NMR (DMSO-d6): δ 10.01 (s, 1H), 7.63 (m, 1H), 7.51-7.57 (m, 1H), 7.36-7.43 (m, 2H), 7.25-7.30 (m, 2H), 7.19 (d, J=8.32 Hz, 1H), 4.27 (s, 2H), 1.59 (s, 6H); MS (ESI) m/z 286 ([M+H]+); MS (ESI) m/z 284 ([M−H]−).

Sources & evidence

ORD record
ord-a2827fde441841d78b20e20d3e7759fc
Source dataset
uspto-grants-2008_01
Patent number
US07323455B2

Reaction notes

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