3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) → HCID 44585536, compound

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Reaction Steps

Prepared from 7-bromo-5,5-diphenyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one and 3-chloro-4-fluoro benzeneboronic acid generally according to the coupling procedure described in example 1. 1H NMR (DMSO-d6): δ 10.17 (s, 1H), 7.65 (dd, J=8.3, 2.44 Hz, 1H), 7.50 (dd, J=7.32, 2.44 Hz, 1H), 7.34-7.43 (m, 7H), 7.25 (d, J=8.3 Hz, 1H), 7.22-7.24 (m, 1H), 7.16-7.19 (m, 4H), 6.75 (d, 1.95 Hz, 1H), 4.26 (s, 2H); MS (ESI) m/z 442/444 ([M−H]−); Anal. calcd for C27H19ClFNO2: C: 73.06; H: 4.31; N: 3.16 Found: C: 72.67; H: 4.36; N: 2.89.

Provenance & Evidence