HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Dimethylamino-3'-trifluoromethylacrylophenone → 4-(alpha,alpha,alpha-Trifluoro-m-tolyl)-8-bromoimidazo[1,5-a]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| Reactant | 5-bromo-1H-imidazol-4-amine | HCID 23329825 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-(alpha,alpha,alpha-Trifluoro-m-tolyl)-8-bromoimidazo[1,5-a]pyrimidine | HCID 23329834 | — |
Reaction Steps
A mixture of 0.01 mole of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 0.01 mole of 4-amino-5-bromoimidazole and 50 ml. of glacial acetic acid is refluxed for 6 hours. The solvent is removed and the residue worked up as for Example 29 to give the product of the example.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04236005 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-275d49dace404ac4a3b38cf9404e6461 |
| Source note | uspto-grants-1980_11 |