3-Aminobenzonitrile → HCID 10151124, compound

HRID 2252657Notes

Reaction equation

[C:1]([C:3]1[CH:4]=C(C=CC=1)N)#N.[CH3:10][N:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:22]=[CH:21][N:20]=[C:19]([NH:23][C:24]3[CH:25]=[C:26]([CH:29]=[CH:30][CH:31]=3)[C:27]#[N:28])[N:18]=2)[CH:13]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:12]1=[O:38]>>[CH:4]1([CH2:10][N:11]2[CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][N:20]=[C:19]([NH:23][C:24]4[CH:25]=[C:26]([CH:29]=[CH:30][CH:31]=4)[C:27]#[N:28])[N:18]=3)[CH:13]([C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)[C:12]2=[O:38])[CH2:3][CH2:1]1

Participants

Reactant 2

HCID 167023-Aminobenzonitrile

HCID 10126479HCID 10126479, compound

Product 1

HCID 10151124HCID 10151124, compoundYield 72%

Procedure

Intermediate 4, (0.20 g, 0.58 mmol) and 3-cyanoaniline (0.14 g, 1.17 mmol) were reacted together following the procedure detailed for the compound of Example 2 which gave the title compound as a pale yellow solid (0.18 g, 72%).

Sources & evidence

ORD record: ord-7b1d24df764342bdaf7303e6bb2c7dda
Source dataset: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07323464B2

Reaction notes

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