3-Dimethylamino-3'-trifluoromethylacrylophenone → HCID 23329830, compound

HRID 225266Notes

Reaction equation

HRID 225266 reaction equation
C[N:2]([CH3:17])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)=O.NC1[N:20]=[CH:21][NH:22][C:23]=1[Cl:24]>C(O)(=O)C>[F:16][C:13]([F:14])([F:15])[C:9]1[CH:10]=[CH:11][CH:12]=[C:7]([C:5]2[N:20]3[CH:21]=[N:22][C:23]([Cl:24])=[C:17]3[N:2]=[CH:3][CH:4]=2)[CH:8]=1

Participants

4

Reactant 2

HCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenoneHCID 23329852HCID 23329852, compound

Product 1

HCID 23329830HCID 23329830, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 0.01 mole of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 40 ml. of glacial acetic acid and 0.01 mole of 4-amino-5-chloroimidazole is refluxed for 6 hours. The solvent is removed under reduced pressure and the residue worked up as for Example 29 to give the product of the example.

Workup

  1. customThe solvent is removed under reduced pressure
  2. customto give the product of the example

Sources & evidence

ORD record
ord-c29520b6976d400a94fd6a81aaac1afd
Source dataset
uspto-grants-1980_11
Patent number
US04236005

Reaction notes

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