Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Aminoimidazole-4-carboxamide hydrochloride → 4-(m-Methoxyphenyl)imidazo[1,5-a]pyrimidine-8-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Aminoimidazole-4-carboxamide hydrochloride | HCID 66146 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 반응물 | 3-Dimethylamino-3'-methoxyacrylophenone | HCID 42573796 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 4-(m-Methoxyphenyl)imidazo[1,5-a]pyrimidine-8-carboxamide | HCID 14677474 | — |
반응 단계
A mixture of 1.62 g. of 4-amino-5-imidazolecaboxamide hydrochloride, 3-dimethylamino-3'-methoxyacrylophenone, 0.82 g. of sodium acetate and 25 ml. of glacial acetic acid is refluxed for 10 hours. The mixture is evaporated to dryness and the residue worked up to give 4-(m-methoxyphenyl)imidazo[1,5-a]pyrimidine-8-carboxamide. This compound is treated as for Example 29 with trifluoroacetic anhydride to give the product of the example.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04236005 |
| 출처 데이터셋 | uspto-grants-1980_11 |
| ORD ID | ord-12c217d117a749b1a77ed7237de14d30 |
| 출처 메모 | uspto-grants-1980_11 |