反应详情

A mixture of 1.55 g. of ethyl 5-aminoimidazole-4-carboxylate and 1.75 g. of 3-dimethylaminoacrylophenone in 25 ml. glacial acetic acid is refluxed for 6 hours and when cooled no precipitate formed. The reaction is evaporated to dryness and dissolved in methylene chloride. After being washed with a saturated sodium bicarbonate solution and dried with anhydrous sodium sulfate, the solution was passed through a short column of hydrous magnesium silicate. Hexane addition to this solution gave the desired product, m.p. 200°-204° C.

1. additionA mixture of 1.55 g
2. temperaturewhen cooled no precipitate
3. customformed
4. customThe reaction is evaporated to dryness
5. dissolutiondissolved in methylene chloride
6. washAfter being washed with a saturated sodium bicarbonate solution
7. dry with materialdried with anhydrous sodium sulfate
8. additionHexane addition to this solution