HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2252799Generated: November 2, 2026
Sodium Azide → 1-(Azidomethyl)-4-fluoro-2-iodobenzene
https://huagongshe.com/reaction/2252799
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 1-(Bromomethyl)-4-fluoro-2-iodobenzene | HCID 12806054 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(Azidomethyl)-4-fluoro-2-iodobenzene | HCID 21069776 | — |
Reaction Steps
A suspension of 1-(bromomethyl)-4-fluoro-2-iodobenzene (15.68 g, 47.8 mmol) and sodium azide (4.21 g, 64.7 mmol) in dry DMF (30 mL) was heated to 50° C. for six hours. The reaction was filtered and the filtrate was concentrated in vacuo to a volume of about 10 mL. The crude was purified by flash column chromatography (ISCO column, 110 g silica gel) eluting with 100% hexane to afford the desired product as a clear oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07323460B2 |
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| Source dataset | uspto-grants-2008_01 |
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| ORD ID | ord-ef3627cca055460b918fa692e04cb783 |
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| Source note | uspto-grants-2008_01 |
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