HCID 59645229, compound → HCID 3013403, compound

HRID 2252816Notes

Reaction equation

HRID 2252816 reaction equation
[Cl-].[NH2:2][C:3]([C:5]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:6]=1[CH2:12][NH3+:13])=[O:4].[OH:14][C:15]1[C:16]([C:31](O)=[O:32])=[N:17][C:18]([N:25]([CH3:30])[S:26]([CH3:29])(=[O:28])=[O:27])=[C:19]2[C:24]=1[N:23]=[CH:22][CH:21]=[CH:20]2>>[NH2:2][C:3]([C:5]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:6]=1[CH2:12][NH:13][C:31]([C:16]1[C:15]([OH:14])=[C:24]2[C:19]([CH:20]=[CH:21][CH:22]=[N:23]2)=[C:18]([N:25]([CH3:30])[S:26]([CH3:29])(=[O:28])=[O:27])[N:17]=1)=[O:32])=[O:4]

Participants

3

Reactant 2

HCID 59645229HCID 59645229, compoundHCID 86600178HCID 86600178, compound

Product 1

HCID 3013403HCID 3013403, compound

Procedure

In a similar manner as described for Example 7, Step 3, [2-(aminocarbonyl)4-fluorophenyl]methanaminium chloride (from Example 9, Step 3) was coupled with 8-hydroxy-5-[methyl(methylsulfonyl)amino]-1,6-naphthyridine-7-carboxylic acid (from Example 5, Step 3) to afford the title compound.

Sources & evidence

ORD record
ord-4cef9c4c128848cf92e083b3ba6e96b7
Source dataset
uspto-grants-2008_01
Patent number
US07323460B2

Reaction notes

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