反应详情

温度

80 °C

Under an N2 atmosphere, 250 mg (0.93 mmol) of 1-chloro-4-(2-pyridin-3-yl-ethyl)isoquinoline in 2.9 ml of abs. ethanol are mixed with 131 mg (1.02 mmol) of 4-chloro-aniline and 0.23 ml of 4 N HCl/dioxane, and stirred for 8 h at 80° C. The mixture is cooled to RT, filtered and the residue washed with acetonitrile. The residue is dissolved in 4 ml of water, then 0.9 ml of sat. NH3 solution are added, stirring is effected for 10 min, the precipitate is filtered off and washed with water. Recrystallisation from acetonitrile yields 1-(4chloroanilino)-4-[2-(pyridin-3-yl)-ethyl]-isoquinoline; m.p.157-158° C.

1. temperatureThe mixture is cooled to RT
2. filtrationfiltered
3. washthe residue washed with acetonitrile
4. dissolutionThe residue is dissolved in 4 ml of water
5. addition0.9 ml of sat. NH3 solution are added
6. stirringstirring
7. waitis effected for 10 min
8. filtrationthe precipitate is filtered off
9. washwashed with water
10. customRecrystallisation from acetonitrile