Ethyl 3-oxo-3-[3-(trifluoromethyl)phenyl]propanoate → HCID 178515578, compound

HRID 225285Notes

Reaction equation

HRID 225285 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.[F:7][C:8]([F:24])([F:23])[C:9]1[CH:10]=[C:11]([CH:20]=[CH:21][CH:22]=1)[C:12]([CH2:14][C:15](OCC)=[O:16])=O>>[OH:16][C:15]1[N:3]2[N:4]=[CH:5][CH:6]=[C:2]2[N:1]=[C:12]([C:11]2[CH:10]=[C:9]([C:8]([F:7])([F:23])[F:24])[CH:22]=[CH:21][CH:20]=2)[CH:14]=1

Participants

3

Reactant 2

HCID 2063905Ethyl 3-oxo-3-[3-(trifluoromethyl)phenyl]propanoateHCID 178418806HCID 178418806, compound

Product 1

HCID 178515578HCID 178515578, compound

Procedure

A mixture of 0.83 g. of 3-aminopyrazole and 2.61 g. of ethyl m-trifluoromethylbenzoylacetate is heated on a steam bath for 2 hours. After cooling the desired compound is collected by filtration, m.p. 305°-310° C.

Workup

  1. additionA mixture of 0.83 g

Sources & evidence

ORD record
ord-c49d0b41ac5a4677abe4f6d246eb8dd8
Source dataset
uspto-grants-1980_11
Patent number
US04236005

Reaction notes

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