3-Dimethylamino-3'-trifluoromethylacrylophenone → HCID 23329821, compound

HRID 225289Notes

Reaction equation

HRID 225289 reaction equation
[NH2:1][C:2]1[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[C:5]([CH2:12][CH3:13])[NH:4][N:3]=1.CN(C)[CH:16]=[CH:17][C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=1)=O>>[CH2:12]([C:5]1[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[C:2]2[N:1]=[CH:16][CH:17]=[C:18]([C:20]3[CH:21]=[C:22]([C:26]([F:27])([F:28])[F:29])[CH:23]=[CH:24][CH:25]=3)[N:3]2[N:4]=1)[CH3:13]

Participants

3

Reactant 2

HCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenoneHCID 15186424Ethyl 3-amino-5-ethyl-1H-pyrazole-4-carboxylate

Product 1

HCID 23329821HCID 23329821, compound

Procedure

As for Example 1, ethyl 3-amino-5-ethyl-pyrazole-4-carboxylate is reacted with 3-dimethylamino-3'-(trifluoromethyl)acrylophenone to give the product as crystals, m.p. 142°-143° C.

Sources & evidence

ORD record
ord-1b55f527f69b411b82ca285fef0684e2
Source dataset
uspto-grants-1980_11
Patent number
US04236005

Reaction notes

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