Trifluoroacetic acid → HCID 11565325, compound

Participants

Reaction Steps

Intermediate (a), N-Boc-(R)-2-(4-methoxy-3-trifluoromethylbenzyl)morpholine (23 mg, 0.06 mmol), was deprotected using trifluoroacetic acid, (20% v/v solution in dichloromethane, 1 mL total) over 2.5 hrs. The reaction mixture was poured onto an SCX-2 column (2 g) and washed with dichloromethane (2 mL×2) and dichloromethane: methanol (1:1 v/v, 2 mL×2). The column was then washed with ammonia (2N solution in methanol, 2 mL×3) and the ammonia washes were concentrated in vacuo to yield the desired morpholine, example 2 as a white solid (15 mg, 89%).

Provenance & Evidence