N-Boc-(R)-2-(4-benzyloxybenzyl)morpholine → N-BOC-(R)-2-(4-hydroxybenzyl)morpholine

Participants

Reaction Conditions

Reaction Steps

To a solution of the intermediate (c), N-Boc-(R)-2-(4-benzyloxybenzyl)morpholine (4.92 g, 12.8 mmol) in ethanol (100 mL), was added 10% palladium on charcoal (1.3 g, 1.28 mmol) and the flask flushed with hydrogen. The mixture was stirred at 38° C. for 16 h then filtered through celite and concentrated to afford the product intermediate (b), N-BOC-(R)-2-(4-hydroxybenzyl)morpholine, as a brown oil (3.7 g, 99%).

Provenance & Evidence