HCID 67073417, compound → HCID 11543824, compound

Participants

Reaction Steps

N-Boc-(R)-2-(4-ethoxy-3-trifluoromethylbenzyl)morpholine, intermediate (a), was dissolved in TFA, (20% v/v solution in dichloromethane, 1.2 mL total) over 3 hrs. The reaction mixture was poured onto an SCX-2 column (2 g) and washed with dichloromethane (2 mL×2) and methanol (2 mL×2). The column was then washed with ammonia (2N solution in methanol, 2 mL×3) and the ammonia washes were concentrated in vacuo to yield the desired morpholine, example 10 as a yellow oil (17 mg, 85%).

Provenance & Evidence