HCID 86607058, compound → HCID 86607057, compound

Participants

Reaction Steps

Intermediate (a) N-BOC-(R)-2-(3-hydroxyimino-4-methoxybenzyl)morpholine (85 mg, 0.24 mmol) was dissolved in TFA (20% v/v in dichloromethane, 5 mL total) and stirred at room temperature for 2 hrs. The reaction mixture was added directly to an SCX-2 column (1 g) and washed with dichloromethane (2 mL×2) and methanol (2 mL×2). The SCX-2 column was then washed with ammonia (2N in methanol, 3×2 mL). Combined ammonia washes were concentrated in vacuo to yield the crude product as a yellow solid (38 mg). The crude material was purified by HPLC to yield the desired morpholine example 25 as a white powder (12 mg).

Provenance & Evidence