HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (r)-2-[3-Chloro-4-(tetrahydro-furan-2-ylmethoxy)-benzyl]-morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tetrahydrofurfuryl alcohol | HCID 7360 | — |
| Reactant | n-Boc-(r)-2-(3-chloro-4-hydroxybenzyl)morpholine | HCID 67073025 | — |
| Reactant | N-Boc-(R)-2-(3-(2-(3-pyridinyl)vinyl)-benzyl)morpholine | HCID 67073511 | — |
| Product | (r)-2-[3-Chloro-4-(tetrahydro-furan-2-ylmethoxy)-benzyl]-morpholine | HCID 67073384 | — |
Reaction Steps
Example 52 was prepared using the same procedure as described for example 7 starting from example 7, intermediate (a), N-BOC-(R)-2-(3-chloro-4-hydroxybenzyl)morpholine and tetrahydrofurfuryl alcohol. The resulting intermediate was deprotected with TFA as described for example 7 to yield the desired morpholine example 52 as a colorless oil (26 mg, 52% over 2 steps) after purification by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07323466B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-df3ea5b0fafe47c6b0e8c753a31eb690 |
| Source note | uspto-grants-2008_01 |