N-bromobutanimide → HCID 67073348, compound

Participants

Reaction Steps

N-bromosuccinimide (29 mg, 0.16 mmol) was added to a solution of N-Boc-(R)-2-(2,4-dimethoxy-benzyl)-morpholine (54 mg, 0.16 mmol) in acetonitrile (6.0 mL). The mixture was shaken for 66 h, concentrated and the residue partitioned between ethyl acetate and water. The organic phase was separated, dried and concentrated to give N-Boc-(R)-2-(5-bromo-2,4-dimethoxy-benzyl)-morpholine which was immediately deprotected using hydrogen chloride (4M in dioxane) in methanol affording example 57 as a brown oil (55 mg, 100%).

Provenance & Evidence