HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (r)-2-(3-Bromo-4-butoxy-benzyl)-morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Butyl bromide | HCID 8002 | — |
| Reactant | N-BOC-(R)-2-(3-bromo-4-hydroxybenzyl)morpholine | HCID 67073493 | — |
| Reactant | N-Boc-(R)-2-(3-(2-(3-pyridinyl)vinyl)-benzyl)morpholine | HCID 67073511 | — |
| Product | (r)-2-(3-Bromo-4-butoxy-benzyl)-morpholine | HCID 11493607 | — |
Reaction Steps
Example 61 was prepared using the same procedure as described for example 4, starting from N-BOC-(R)-2-(3-bromo-4-hydroxybenzyl)morpholine, example 4, intermediate (a), and 1-bromobutane. The resulting intermediate was deprotected with TFA as described for example 4 to yield the desired morpholine example 61 as a colorless oil (28 mg, 63% over 2 steps) after purification by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07323466B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-0703e5b21ead4f74b1dcb85fd4fe70b8 |
| Source note | uspto-grants-2008_01 |