(-)-Epichlorohydrin → (r)-2-(2,2-Difluoro-benzo [1,3]dioxol-4-ylmethyl)-morpholine

Participants

Role	Name	HCID	Charge
Reactant	(-)-Epichlorohydrin	HCID 2734062	—
Reactant	4-Bromo-2,2-difluoro-1,3-benzodioxole	HCID 2773297	—
Reactant	(R)-1-chloro-3-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-2-propanol	HCID 67073115	—
Reactant	N-Boc-(R)-2-(3-bromobenzyl)morpholine	HCID 67073309	—
Product	(r)-2-(2,2-Difluoro-benzo [1,3]dioxol-4-ylmethyl)-morpholine	HCID 11658928	—
Product	(R)-1-chloro-3-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-2-propanol	HCID 67073115	—

Reaction Steps

(R)-1-chloro-3-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-2-propanol was prepared using the same procedure as described for example 2, intermediate (d), but from 4-bromo-2,2-difluoro-benzo[1,3]dioxole and (R)-epichlorohydrin. Example 66 was prepared as described for example 1, intermediate (d), but using (R)-1-chloro-3-(2,2-Difluoro-benzo[1,3]dioxol-4-yl)-2-propanol, to obtain the desired morpholine example 66, as a colorless liquid, (0.214 g, 13.6%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07323466B2
Source dataset	uspto-grants-2008_01
ORD ID	ord-5a03bf1473ab460f9c59444c089fb8ba
Source note	uspto-grants-2008_01