HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (r)-2-[3-(2-Pyridin-2-yl-ethyl)-benzyl]-morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2-Vinylpyridine | HCID 7521 | — |
| Reactant | N-Boc-(R)-2-(3-(hydroxymethyl)benzyl)morpholine | HCID 67073062 | — |
| Reactant | N-Boc-(R)-2-(3-bromobenzyl)morpholine | HCID 67073309 | — |
| Product | (r)-2-[3-(2-Pyridin-2-yl-ethyl)-benzyl]-morpholine | HCID 11529280 | — |
Reaction Steps
Example 69 was prepared using the procedure as described for example 31, but starting with N-Boc-(R)-2-(3-bromobenzyl)morpholine, example 31, intermediate (b), and 2-vinylpyridine. The resulting intermediate was deprotected with TFA as described for example 4 to yield the desired morpholine example 68 as a yellow oil (16 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07323466B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-12d7489f4ff1402aad274ea52c35217f |
| Source note | uspto-grants-2008_01 |