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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2253023Generated: November 2, 2026

Borane → N-benzyl-2-(2-difluoromethoxy-benzyl)-morpholine

https://huagongshe.com/reaction/2253023

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBoraneHCID 6331—
ReactantN-benzyl-2-(2-difluoromethoxy-benzyl)-morpholin-3-oneHCID 67073097—
ReactantN-Boc-(R)-2-(3-(2-(3-pyridinyl)vinyl)-benzyl)morpholineHCID 67073511—
ProductN-benzyl-2-(2-difluoromethoxy-benzyl)-morpholineHCID 67073057—

Reaction Steps

N-Benzyl-2-(2-difluoromethoxy-benzyl)-morpholine was prepared as described for example 70, intermediate (a), but using N-benzyl-2-(2-difluoromethoxy-benzyl)-morpholin-3-one and borane and was isolated as a pale yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07323466B2
Source datasetuspto-grants-2008_01
ORD IDord-375723f8d3cd4f86889e5973d5020021
Source noteuspto-grants-2008_01