Borane → N-benzyl-2-(3-methylbenzyl)-morpholine

HRID 2253026Notes

Reaction equation

HRID 2253026 reaction equation
C(N1CCO[C@H](CC2C=CC=C(C=CC3C=NC=CC=3)C=2)C1)(OC(C)(C)C)=O.[CH2:29]([N:36]1[CH2:41][CH2:40][O:39][CH:38]([CH2:42][C:43]2[CH:48]=[CH:47][CH:46]=[C:45]([CH3:49])[CH:44]=2)[C:37]1=O)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.B>>[CH2:29]([N:36]1[CH2:41][CH2:40][O:39][CH:38]([CH2:42][C:43]2[CH:48]=[CH:47][CH:46]=[C:45]([CH3:49])[CH:44]=2)[CH2:37]1)[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

4

Reactant 3

HCID 6331BoraneHCID 67073470N-benzyl-2-(3-methylbenzyl)-morpholin-3-oneHCID 67073511N-Boc-(R)-2-(3-(2-(3-pyridinyl)vinyl)-benzyl)morpholine

Product 1

HCID 67073243N-benzyl-2-(3-methylbenzyl)-morpholine

Procedure

N-Benzyl-2-(3-methylbenzyl)-morpholine was prepared as described for example 70, intermediate (a), but using N-benzyl-2-(3-methylbenzyl)-morpholin-3-one and borane and was isolated as a pale yellow oil.

Workup

  1. customwas isolated as a pale yellow oil

Sources & evidence

ORD record
ord-2fb7dc264b4b4ab18f54b09462634494
Source dataset
uspto-grants-2008_01
Patent number
US07323466B2

Reaction notes

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