m-Xylyl bromide → N-benzyl-2-(3-methylbenzyl)-morpholin-3-one

HRID 2253027Notes

Reaction equation

HRID 2253027 reaction equation
C(N1CCO[C@H]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21]O)[CH:16]=2)C1)(OC(C)(C)C)=O.[CH2:23]([N:30]1[CH2:35][CH2:34][O:33][CH2:32][C:31]1=[O:36])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.CC1C=C(C=CC=1)CBr>>[CH2:23]([N:30]1[CH2:35][CH2:34][O:33][CH:32]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[CH:16]=2)[C:31]1=[O:36])[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

4

Reactant 3

HCID 12099m-Xylyl bromideHCID 122940874-Benzylmorpholin-3-oneHCID 67073062N-Boc-(R)-2-(3-(hydroxymethyl)benzyl)morpholine

Product 1

HCID 67073470N-benzyl-2-(3-methylbenzyl)-morpholin-3-one

Procedure

N-Benzyl-2-(3-methylbenzyl)-morpholin-3-one was prepared as described for example 70, intermediate (b), but using 4-benzylmorpholine-3-one and 3-methylbenzyl bromide and was isolated as a pale yellow oil.

Workup

  1. customwas isolated as a pale yellow oil

Sources & evidence

ORD record
ord-45d94fe4050648f9865ac0902907f25f
Source dataset
uspto-grants-2008_01
Patent number
US07323466B2

Reaction notes

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