3-(Bromomethyl)-5-methylisoxazole → HCID 11709591, compound

HRID 2253033Notes

Reaction equation

HRID 2253033 reaction equation
C(N1CCO[C@H](CC2C=CC=C(C=CC3C=NC=CC=3)C=2)C1)(OC(C)(C)C)=O.Br[CH2:30][C:31]1[CH:35]=[C:34]([CH3:36])[O:33][N:32]=1.C(OC([N:44]1[CH2:49][CH2:48][O:47][C@H:46]([CH2:50][C:51]2[CH:56]=[C:55]([F:57])[C:54]([OH:58])=[CH:53][C:52]=2[F:59])[CH2:45]1)=O)(C)(C)C>>[F:59][C:52]1[CH:53]=[C:54]([O:58][CH2:30][C:31]2[CH:35]=[C:34]([CH3:36])[O:33][N:32]=2)[C:55]([F:57])=[CH:56][C:51]=1[CH2:50][C@H:46]1[O:47][CH2:48][CH2:49][NH:44][CH2:45]1

Participants

4

Reactant 3

HCID 27763043-(Bromomethyl)-5-methylisoxazoleHCID 67073121HCID 67073121, compoundHCID 67073511N-Boc-(R)-2-(3-(2-(3-pyridinyl)vinyl)-benzyl)morpholine

Product 1

HCID 11709591HCID 11709591, compound

Procedure

The title compound was synthesized in analogy to Example 78, intermediate (a), using 3-(bromomethyl)-5-methylisoxazol and (R)-2-(2,5-difluoro-4-hydroxy-benzyl)-morpholine-4-carboxylic acid tert-butyl ester as starting materials.

Sources & evidence

ORD record
ord-0557e66b93bc4e7e9298bf34d859a59d
Source dataset
uspto-grants-2008_01
Patent number
US07323466B2

Reaction notes

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