Dichloromethane → HCID 86607061, compound

Participants

Reaction Conditions

Reaction Steps

To the solution of 1.80 g (5.5 mmol) (R)-2-(3-chloro-4-hydroxy-benzyl)-morpholine-4-carboxylic acid tert-butyl ester (example 7, intermediate (a)) in 25 mL dichloromethane 1.53 mL (11.0 mmol) triethylamine were added. After cooling down to 0° C. 1.0 mL (6.0 mmol) trifluoromethanesulfonic anhydride were added and the cooling bath was removed. After 1 h stirring at room temperature the reaction mixture was extracted with 10% aqueous sodium bicarbonate solution and brine and the organic layer was dried over magnesium sulfate, filtered and evaporated. The residue was purified by column chromatography on silica gel using n-hexane:ethyl acetate (2:1 v/v) as eluant to give the compound in form of a light yellow oil (98%).

Provenance & Evidence