HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-methylbenzeneboronic acid → (R)-2-(2-Chloro-3'-fluoro-4'-methyl-biphenyl-4-ylmethyl)-morpholine-4-carboxylic Acid Tert-butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-methylbenzeneboronic acid | HCID 2782674 | — |
| Reactant | N-Boc-(R)-2-(3-(2-(3-pyridinyl)vinyl)-benzyl)morpholine | HCID 67073511 | — |
| Reactant | HCID 86607061 | HCID 86607061 | — |
| Product | (R)-2-(2-Chloro-3'-fluoro-4'-methyl-biphenyl-4-ylmethyl)-morpholine-4-carboxylic Acid Tert-butyl Ester | HCID 67073249 | — |
Reaction Steps
The title compound was synthesized in analogy to example 80, intermediate (a), from (R)-2-(3-chloro-4-trifluoromethanesulfonyloxy-benzyl)-morpholine-4-carboxylic acid tert-butyl ester and 3-fluoro-4-methylbenzeneboronic acid to give the compound as a colorless oil (97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07323466B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-7ffd8ee697654385bdbbaa77dbddfb6c |
| Source note | uspto-grants-2008_01 |