HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → alpha-Amino-4-hydroxy-3-(methoxymethyl)benzeneacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (-)-alpha-Amino-4-hydroxy-3-(methoxymethyl)benzeneacetic acid methyl ester | HCID 53644499 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | alpha-Amino-4-hydroxy-3-(methoxymethyl)benzeneacetic acid | HCID 23329768 | — |
Reaction Steps
(-)-α-Amino-4-hydroxy-3-(methoxymethyl)benzeneacetic acid methyl ester is dissolved in aqueous 1 N sodium hydroxide and the solution is stirred at 40°-50° C. for 1 hour. The solution is acidified with 6 N hydrochloric acid to a pH of 7. Evaporation of the solvent gives the title compound in a 90% overall yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04236002 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-af841033f58e4f8598fea6d220f4ff2f |
| Source note | uspto-grants-1980_11 |