HCID 20296133, compound → HCID 23329777, compound

HRID 225318Notes

Reaction equation

HRID 225318 reaction equation
[NH2:1][C:2]([NH:4][CH:5]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([CH2:16]Cl)[CH:10]=1)[C:6]([OH:8])=[O:7])=[O:3].[H][H]>O.[Pd]>[NH2:1][C:2]([NH:4][CH:5]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([CH3:16])[CH:10]=1)[C:6]([OH:8])=[O:7])=[O:3]

Participants

5

Reactant 2

HCID 20296133HCID 20296133, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23329777HCID 23329777, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

A mixture of α-(aminocarbonyl)amino-3-chloromethyl-4-hydroxybenzeneacetic acid (0.1 mole) and 10% Pd on charcoal (1 g) catalyst in 50 ml of water is subjected to hydrogen gas at a pressure of about 60 pounds/in2 at room temperature for a period of about 16 hours. Removal of the catalyst followed by evaporation of the water gives the title compound.

Workup

  1. customin2 at room temperature
  2. customof about 16 hours
  3. customRemoval of the catalyst
  4. customfollowed by evaporation of the water

Sources & evidence

ORD record
ord-c90482b4dae24a99bcf04693eaf6829b
Source dataset
uspto-grants-1980_11
Patent number
US04236002

Reaction notes

Loading…