Hydrochloric Acid → HCID 135511908, compound

Participants

Reaction Steps

A mixture of the compound from Step F in 2N aqueous NaOH is stirred at reflux temperature for 1.5 h. The solution is cooled in an ice-bath, neutralized with 2 N aqueous HCl and evaporated to dryness. The residue is suspended in MeOH, mixed with silica gel and evaporated. The solid residue is placed onto a silica gel column (packed in a solvent system of CH2Cl2/MeOH). The compound is eluted with a solvent system of CH2Cl2/MeOH. The fractions containing the product are collected and evaporated to dryness to yield the title compound 2-7.

Provenance & Evidence