HCID 12291813, compound → HCID 69130263, compound

HRID 2253279Notes

Reaction equation

HRID 2253279 reaction equation
[NH2:1][CH2:2][C:3]([N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1)=[O:4].[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:21]=[C:22]([C:28]2[CH:45]=[CH:44][C:31]([O:32][C:33]3[CH:38]=[CH:37][C:36]([CH2:39][CH2:40][C:41](O)=[O:42])=[CH:35][CH:34]=3)=[CH:30][CH:29]=2)[C:23](=[O:27])[N:24]([CH3:26])[CH3:25])[CH:16]=[C:17]([O:19][CH3:20])[CH:18]=1>>[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:21]=[C:22]([C:28]2[CH:45]=[CH:44][C:31]([O:32][C:33]3[CH:38]=[CH:37][C:36]([CH2:39][CH2:40][C:41](=[O:42])[NH:1][CH2:2][C:3]([N:5]4[CH2:10][CH2:9][O:8][CH2:7][CH2:6]4)=[O:4])=[CH:35][CH:34]=3)=[CH:30][CH:29]=2)[C:23]([N:24]([CH3:26])[CH3:25])=[O:27])[CH:16]=[C:17]([O:19][CH3:20])[CH:18]=1

Participants

3

Reactant 2

HCID 12291813HCID 12291813, compoundHCID 69130583HCID 69130583, compound

Product 1

HCID 69130263HCID 69130263, compound

Procedure

Following the general procedure for conversion of carboxylic acids to amides mentioned above and using 2-amino-1-morpholin-4-yl-ethanone as amine, 3-(4-{4-[2-(3,5-dimethoxyphenyl)-1-dimethylcarbamoylvinyl]-phenoxy}-phenyl)-propionic acid, 38, was converted to 63.

Sources & evidence

ORD record
ord-eb26ef7399a14cc19a9d89cfe1285ab6
Source dataset
uspto-grants-2008_01
Patent number
US07323496B2

Reaction notes

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