HRID2253279

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12291813

未命名化合物

结构：COc1cc(C=C(C(=O)N(C)C)c2ccc(Oc3ccc(CCC(=O)O)cc3)cc2)cc(OC)c1

HCID69130583

未命名化合物

PRODUCTS

生成物

结构：COc1cc(C=C(C(=O)N(C)C)c2ccc(Oc3ccc(CCC(=O)NCC(=O)N4CCOCC4)cc3)cc2)cc(OC)c1

HCID69130263

未命名化合物

PROCEDURE

实验过程

Following the general procedure for conversion of carboxylic acids to amides mentioned above and using 2-amino-1-morpholin-4-yl-ethanone as amine, 3-(4-{4-[2-(3,5-dimethoxyphenyl)-1-dimethylcarbamoylvinyl]-phenoxy}-phenyl)-propionic acid, 38, was converted to 63.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-eb26ef7399a14cc19a9d89cfe1285ab6
来源数据集: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07323496B2
来源说明: uspto-grants-2008_01

反应 SMILES

[NH2:1][CH2:2][C:3]([N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1)=[O:4].[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:21]=[C:22]([C:28]2[CH:45]=[CH:44][C:31]([O:32][C:33]3[CH:38]=[CH:37][C:36]([CH2:39][CH2:40][C:41](O)=[O:42])=[CH:35][CH:34]=3)=[CH:30][CH:29]=2)[C:23](=[O:27])[N:24]([CH3:26])[CH3:25])[CH:16]=[C:17]([O:19][CH3:20])[CH:18]=1>>[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:21]=[C:22]([C:28]2[CH:45]=[CH:44][C:31]([O:32][C:33]3[CH:38]=[CH:37][C:36]([CH2:39][CH2:40][C:41](=[O:42])[NH:1][CH2:2][C:3]([N:5]4[CH2:10][CH2:9][O:8][CH2:7][CH2:6]4)=[O:4])=[CH:35][CH:34]=3)=[CH:30][CH:29]=2)[C:23]([N:24]([CH3:26])[CH3:25])=[O:27])[CH:16]=[C:17]([O:19][CH3:20])[CH:18]=1