反应详情

温度

25 °C

Bromine (9.27 mL, 188.6 mmol) was added dropwise to a solution of 7-amino-4,4-dimethyl-8-nitroisoquinoline-1,3(2H,4H)-dione (4.70 g, 18.86 mmol) in AcOH (190 mL). The reaction mixture was stirred at 25° C. for 2 h then was concentrated under reduced pressure. The residue was diluted with EtOAc, and successively washed with water, aqueous saturated NaHCO3, aqueous saturated Na2S2O3, and brine, dried (MgSO4), filtered and concentrated under reduced pressure to give the title compound (6.10 g, 99% yield).

1. concentrationthen was concentrated under reduced pressure
2. additionThe residue was diluted with EtOAc
3. washsuccessively washed with water, aqueous saturated NaHCO3, aqueous saturated Na2S2O3, and brine
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure