Hydrochloric Acid → HCID 12129623, compound

Participants

Reaction Steps

A solution of Example 46B (0.8 g, 2.1 mmol) in methanol (50 mL) at room temperature was treated with SnCl2.2H2O (1.41 g, 6.3 mmol) and concentrated HCl (20 mL), stirred for 12 hours, and concentrated. The concentrate was treated with aqueous NaOH and extracted with ethyl acetate. The combined extracts were washed with brine, dried (MgSO4), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with CH2Cl2:CH3OH:NH4OH (100:3:3, v/v) to provide the desired product. MS (DCI/NH3) m/z 445 (M+H)+.

Provenance & Evidence