Ammonia → Oxane-4-carboxamide

Concentrated aqueous ammonia (50 mL) was added to methyl tetrahydro-2H-pyran-4-carboxylate (50 g, 347 mmol) and the reaction mixture was stirred for 43.5 hours at room temperature. The reaction mixture was then cooled in an ice water bath, after which the precipitate was filtered out and dried under reduced pressure at 40° C. to afford 33.4 g of the title compound (74.6% yield).

1. temperatureThe reaction mixture was then cooled in an ice water bath
2. filtrationafter which the precipitate was filtered out
3. customdried under reduced pressure at 40° C.

ORD record

ord-c0c32dac4367438a8b66284a9fd280c5

Source dataset

uspto-grants-2008_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07323569B2