HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylphosphine → HCID 86612070, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylphosphine | HCID 68983 | — |
| Reactant | HCID 59645497 | HCID 59645497 | — |
| Reactant | HCID 86584891 | HCID 86584891 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | HCID 86612070 | HCID 86612070 | — |
Reaction Steps
(35,6R,7S,8R,12R, 13S,15S,16E)-15-amino-3,7-dihydroxy-5,9-dioxo-12,13-epoxy-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-16-heptadecenoic acid. A solution of (3S,6R,7S,8R,12R,13S,15S,16E)-15-azido-3,7-dihydroxy-5,9-dioxo-12,13-epoxy-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-16-heptadecenoic acid (565 mg) in 15 mL of THF/water (10:1 v/v) is treated with a 1.0 M solution of trimethylphosphine in toluene (3 mL) under argon for 2 hours at ambient temperature. The mixture is concentrated, and the product is purified by flash chromatography on SiO2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07323573B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-fec5a2c100fa4f04bb02b5b6c61d1749 |
| Source note | uspto-grants-2008_01 |