Tetrahydrofuran → HCID 86606707, compound

Participants

Reaction Steps

To a 0° C. solution of (E)-ethyl 4-[tris-(1-methylethyl)silyloxy]-3-methylbut-2-enoate (5 g, 17.6 mmol) in dry Et2O was added a solution of lithium aluminum hydride (17.6 mL, 17.6 mmol, 1 M in Et2O). After 30 minutes, the reaction mixture was neutralized by dropwise addition of THF followed by addition of a saturated solution of potassium sodium tartrate. The reaction mixture was stirred overnight and then diluted with Et2O. The organic layer was separated and washed with water, dried over MgSO4 and concentrated in vacuo to afford (E)-3-[tris-(1-methylethyl)silyloxy]but-2-en-1-ol as a colorless oil which was used directly into the next reaction.

Provenance & Evidence