HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoromethylsulfonamide → C,C,C-trifluoro-N-{3-[4-(6-phenyl-8,9-dihydro-7H-benzocyclohepten-5-yl)-phenyl]-acryloyl}-methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoromethylsulfonamide | HCID 79001 | — |
| Reactant | 3-[4-(6-Phenyl-8,9-dihydro-7H-benzocyclohepten-5-yl)-phenyl]-acrylic acid | HCID 69315044 | — |
| Product | C,C,C-trifluoro-N-{3-[4-(6-phenyl-8,9-dihydro-7H-benzocyclohepten-5-yl)-phenyl]-acryloyl}-methanesulfonamide | HCID 69780904 | — |
Reaction Steps
Prepared by coupling 2e and trifluoromethanesulfonamide in accordance with Procedure 1, Method B described hereinabove. Yield (12%); 1H NMR (d6-DMSO) δ 8.93 (br s, 2H), 7.31-7.07 (m, 9H), 6.80 (d, J=8.0 Hz, 2H), 6.72 (d, J=7.3 Hz, 1H), 6.35 (d, J=15.7 Hz, 1H), 2.76 (t, J=7.0 Hz, 2H), 2.26 (t, J=7.0 Hz, 2H), 2.07 (m, 2H); APcI m/z: 496 (M−H−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07323587B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-6bd2273a980f4c21a0d9fac113827819 |
| Source note | uspto-grants-2008_01 |