Hydrochloric Acid → HCID 19745802, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 6.45 g of 6-[3-(ethoxycarbonylamino)-2-pentenoylamino]-3,4-dihydro-7-fluoro-3-oxo-4-(2-propynyl)-2H-1,4-benzoxazine and 3.22 g of sodium methylate in 6.5 ml of methanol is stirred at 62° C. for 4 hours. The solution which thus results is left to stand at room temperature for 64 hours and subsequently poured into a solution of 15 ml of 2N hydrochloric acid in 400 ml of water. The resulting precipitate is filtered off under suction, washed with water and recrystallized from acetone/n-hexane. In this manner there is obtained 6-ethyl-3-[3,4-dihydro-7-fluoro-3-oxo-4-(2-propynyl)-2H-1,4-benzoxazine-6-yl]-2,4(1H,3H)-pyrimidinedione, m.p. 240° C. (with decomposition).

Provenance & Evidence