Phosgene → 7-fluoro-6-isocyanato-4-propargyl-2H-1,4-benzoxazin-3(4H)-one

Participants

Role	Name	HCID	Charge
Reactant	Phosgene	HCID 6371	—
Reactant	6-amino-7-fluoro-4-(prop-2-yn-1-yl)-3,4-dihydro-2H-1,4-benzoxazin-3-one	HCID 11160323	—
Product	7-fluoro-6-isocyanato-4-propargyl-2H-1,4-benzoxazin-3(4H)-one	HCID 11817439	—

Reaction Steps

6-Amino-3,4-dihydro-7-fluoro-3-oxo-4-(2-propynyl)-2H-1,4-benzoxazine is treated with phosgene analogously to the procedure described in Example 103 in order to produce the 3,4-dihydro-7-fluoro-6-isocyanato-3-oxo-4-(2-propynyl)-2H-1,4-benzoxazine which is used as the starting material in Example 2. 1H-NMR (CDCl3, 60 MHz): 7.02 ppm (d, 1H), 6.88 ppm (d, 1H), 4.88-4.60 ppm (m, 4H), 2.35 ppm (t, 1H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05232898
Source dataset	uspto-grants-1993_08
ORD ID	ord-72c259f01e514eddaa3460c2ce5b8da3
Source note	uspto-grants-1993_08