Phosgene → 3,4-dihydro-6-isocyanato-3-oxo-4-(2-propynyl)-2H-1,4-benzoxazine

Participants

Role	Name	HCID	Charge
Reactant	Phosgene	HCID 6371	—
Reactant	6-amino-4-propargyl-2H-1,4-benzoxazin-3(4H)-one	HCID 13649005	—
Product	3,4-dihydro-6-isocyanato-3-oxo-4-(2-propynyl)-2H-1,4-benzoxazine	HCID 19745827	—

Reaction Steps

6-Amino-3,4-dihydro-3-oxo-4-(2-propynyl)-2H-1,4-benzoxazine is treated with phosgene analogously to the procedure described in Example 103 in order to produce the 3,4-dihydro-6-isocyanato-3-oxo-4-(2-propynyl)-2H-1,4-benzoxazine which is used as the starting material in Example 3. 1H-NMR (CDCl3, 400 MHz): 6.98-6.92 ppm (m, 2H), 6.79 ppm (q, 1H), 4.66 ppm (d, 2H), 4.63 ppm (s, 2H), 2.31 ppm (t, 1H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05232898
Source dataset	uspto-grants-1993_08
ORD ID	ord-d9100664906b492d95ad144c8fc7ce2e
Source note	uspto-grants-1993_08