HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diketene → 5-Acetoacetylamino-6-fluoro-3-(2-propynyl)-2-benzothiazolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diketene | HCID 12661 | — |
| Reactant | 4-Pyrrolidinopyridine | HCID 75567 | — |
| Reactant | 5-Amino-6-fluoro-3-(prop-2-yn-1-yl)-1,3-benzothiazol-2(3H)-one | HCID 13960995 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 5-Acetoacetylamino-6-fluoro-3-(2-propynyl)-2-benzothiazolinone | HCID 19745809 | — |
Reaction Steps
A suspension of 4.7 g of 5-amino-6-fluoro-3-(2-propynyl)-2-benzothiazolinone, 1.93 g of diketene and 0.05 g of 4-pyrrolidinopyridine in 250 ml of benzene is stirred at room temperature for 30 minutes and subsequently held at 50° C. for 30 minutes. In this manner there is obtained a solution of 5-acetoacetylamino-6-fluoro-3-(2-propynyl)-2-benzothiazolinone which is used as such in the next reaction step without isolation of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05232898 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-91a2d8698d2148d7be763773befd8d65 |
| Source note | uspto-grants-1993_08 |