Water → HCID 131718035, compound

Participants

Reaction Steps

29,6 g of 3-[6-fluoro-2-oxo-3-(2-propinyl)-5-benzothiazolinyl]-5-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidindion in 200 ml acetonitrile is stirred with 9,25 g dimethylsulfate and 10,14 g potassium carbonate at 40° C. for 90 minutes. Thereafter, the reaction mixture is poured into 200 ml of water and extracted two times with 200 ml ethyl acetate each time. The organic phase is subsequently concentrated. The thus-obtained residue is purified by chromatography with 400 g silica gel using hexane:ethyl acetate (7:3).

Provenance & Evidence