Thiomorpholine → HCID 15100260, compound

HRID 2253604Notes

Reaction equation

HRID 2253604 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([S:7](Cl)(=[O:9])=[O:8])[N:4]=[CH:3]1.[NH:11]1[CH2:16][CH2:15][S:14][CH2:13][CH2:12]1>C(#N)C>[CH3:1][N:2]1[CH:6]=[C:5]([S:7]([N:11]2[CH2:16][CH2:15][S:14][CH2:13][CH2:12]2)(=[O:9])=[O:8])[N:4]=[CH:3]1

Participants

4

Reactant 2

HCID 67164ThiomorpholineHCID 27368871-methyl-1H-imidazole-4-sulfonyl chloride

Product 1

HCID 15100260HCID 15100260, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

2 g (11 mmol) of 1-methyl-4-imidazolesulfonyl chloride from Example C-1, dissolved in 20 ml of acetonitrile, are added dropwise with stirring at room temperature to a solution of 1.51 ml (15 mmol) of thiomorpholine in 50 ml of acetonitrile. The reaction mixture is subsequently stirred for 6 hours, filtered and evaporated in vacuo. The residue remaining is recrystallized from isopropanol in order to give the title compound of melting point 154°-155° C.

Workup

  1. additionare added dropwise
  2. filtrationfiltered
  3. customevaporated in vacuo
  4. customThe residue remaining is recrystallized from isopropanol in order

Sources & evidence

ORD record
ord-ef7eda3554da4745919a32c012aa09d2
Source dataset
uspto-grants-1993_08
Patent number
US05232922

Reaction notes

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